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Tendances du mois


Un aperçu de la recherche en Normandie

  • From blood tests to living tumor organoids, researchers are turning small molecular signals into big clinical decisions. Across ovarian and breast cancers—and even hereditary cancer risk—new studies show how microRNAs, immune visibility and smarter chemo design can sharpen who gets which therapy and when.
  • In ovarian cancer, Edwige Abeilard and colleagues at Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers ANTICIPE reveal that the lncRNA UCA1 helps tumors dodge cisplatin by sponging miR‑27a‑5p and upholding UBE2N; dialing down UCA1 unleashes BIM and restores drug sensitivity, while UBE2N inhibition also re-sensitizes patient-derived organoids to platinum (study index 97).
  • Homing in on a potent microRNA, Bernard Lambert and team at ANTICIPE show that miR‑3622b‑5p triggers apoptosis in ovarian cancer cells by jointly targeting Bcl‑xL and EGFR, and it sensitizes models to standard drugs—benefits reproduced in patient tumor organoids, hinting at fast translational potential (98).
  • In the bloodstream, Laurent Poulain, Christophe Denoyelle and collaborators from Génomique et médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND) and ANTICIPE report that the serum microRNA miR‑622 foretells who will (or won’t) respond to first‑line chemotherapy for high‑grade serous ovarian cancer, linking levels to progression‑free and overall survival and bolstering the case for pre‑treatment liquid biopsies (344).
  • In breast cancer clinics, A Johnson and a nationwide French cohort coordinated with Cancer and Brain Genomics (CBG) and GPMCND confirm that tumors with very low estrogen receptor (ER‑low) expression behave like triple‑negative disease: adding pembrolizumab to neoadjuvant chemo delivered a striking 71.9% pathologic complete response—evidence to treat ER‑low as ER‑null to maximize cure chances (693).
  • Zooming out to genetics, Jonathan Gaucher, Thierry Frébourg, Pierre Hainaut and an international team from CBG and GPMCND show that in Li‑Fraumeni syndrome, the neoantigenic properties of individual TP53 variants correlate with age at first cancer and tumor spectrum—pointing to variant‑specific immune surveillance as a key driver of risk heterogeneity and a new angle for prevention (695).
  • And in leukemia, the BIG‑1 study led by Dominique Penther with Mobilités : Vieillissement, Pathologie, Santé COMETE UR streamlines induction for younger adults with AML: a single anthracycline‑containing cycle (daunorubicin vs idarubicin) delivered equivalent survival, with daunorubicin causing fewer side effects—establishing a clean backbone on which to add the next generation of targeted drugs (760).

  • Stroke and bleeding emergencies reward speed—and now, smarter timing. New clinical and preclinical work refines when to lyse clots, how to see and dissolve the tiniest microthrombi, and when “more blood” is actually the safer bet for a failing heart.
  • When stroke patients first land at smaller hospitals, giving IV thrombolysis even beyond 4.5 hours—before transfer for thrombectomy—paid off. Nicolas Chausson and colleagues at Laboratoire d’Ondes et Milieux Complexes (LOMC) found better 3‑month outcomes and dramatic en‑route recanalization, without added hemorrhage—evidence to act early rather than wait for arrival at a comprehensive center (590).
  • Microthrombi—the tiny culprits that standard scans miss—met their match in a theranostic platform by Peter Schmidt, Denis Vivien et al. (Mobilités : Vieillissement, Pathologie, Santé COMETE UR; Physiopathologie et imagerie des troubles neurologiques PhIND): iron‑oxide particles wrapped in polydopamine and armed with r‑tPA both light up and dissolve clots under visible/near‑IR light, offering a precision tool for the microcirculation (740).
  • In heart attacks with anemia, transfusion strategy matters. The MINT analysis led by Howard Cooper with the COMETE network suggests a liberal transfusion approach is safe—and a restrictive strategy may underperform in those with baseline heart failure—nudging a nuanced, patient‑specific playbook (606).
  • For severely breathless ICU patients not to be intubated, the OXYPAL multicenter study (COMETE) compares high‑flow nasal oxygen to non‑invasive ventilation, focusing not just on survival but comfort and quality of life—critical outcomes for a population where relief is as important as rescue (607).
  • And in life‑threatening variceal bleeding, Morgane Clement and colleagues (Laboratoire d’Ondes et Milieux Complexes LOMC; COMETE UR) report that esophageal stents control bleeding better by day 5 and reduce 6‑week mortality versus balloon tamponade—reshaping a decades‑old bridge therapy (779).

  • From sub‑Antarctic toothfish to pelagic super‑predators, from forests to coral lagoons, researchers are swapping guesswork for data‑rich maps and rules. The goal: act faster, protect smarter, and measure what really matters for ecosystems under climate stress.
  • Global conservation gets sharper triage with a 256‑species analysis by Enrico Gennari and a worldwide team at Biologie des Organismes et Ecosystèmes Aquatiques (BOREA): drifting longlines, temperature extremes and fixed gear top vulnerability scores, while plastics blanket the largest share of populations—giving managers a frank ledger of where to push hardest (558).
  • To match impact with action, Josie Angulo, Boris Leroy and colleagues at BOREA extend EICAT to EEICAT, a framework that classifies 19 types of ecological impacts from individuals up to ecosystems—so risks can be compared, prioritized and communicated across disciplines and borders (549).
  • In the remote Kerguelen Plateau, Félix Massiot‑Granier and Clara Péron (BOREA) use spawner CPUE and spatial GAMs to pinpoint seasonal hotspots for Patagonian toothfish—evidence to shape localized, time‑bound closures that spare reproducers without crippling fisheries (552).
  • Shallow seas are getting easier to read from space. Pascal Mouquet and Éric Feunteun at BOREA show that superspectral VENµS imagery can, with simple linear models, map bathymetry accurately down to ~10 m—fast, cheap and scalable support for coastal habitat management (551).
  • On land, Erwin Ulrich and a national network at ECODIV find that understory plant indicator values that work well across space falter over time: community indices failed to track long‑term soil chemistry change, urging caution in relying on vegetation to infer subtle temporal shifts (69).

  • While attackers find fresh cracks in exotic RSA‑like schemes, defenders are retraining sensors for an Internet where protocols are encrypted by design. The message: proofs need hardening, and protection mustn’t rely on peeking inside packets.
  • Mohammed Rahmani and Abderrahmane Nitaj at Laboratoire de Mathématiques Nicolas Oresme (LMNO) break an RSA variant based on a cubic Pell curve in the r=s=1 case using Coppersmith’s method—deriving explicit bounds on private keys and tightening the safety margin for implementers (338).
  • In a companion advance, Rahmani, Mhammed Ziane and Nitaj (LMNO) generalize attacks to public exponents of the form e ≡ z/u (mod φ_n(N)), vastly enlarging the class of weak keys—proof that clever number theory still moves practical security (337).
  • Pushing further, Ziane, Nitaj and Rahmani (LMNO) combine Coppersmith with lattice reduction to crack more RSA variants when exponents contain small components and partial prime information leaks—an all‑too‑realistic scenario in embedded systems (658).
  • On the defensive side, Adam Kadi, Lyes Khoukhi and partners at GREYC tailor machine learning to the QUIC era, where payloads are opaque and timing is king—showing how features and models can spot intrusions without decrypting a single byte (536).
    • Les termes à retenir
    Ce nuage de mots-clés représente un échantillon des termes, les plus récents et les plus fréquents au global, associés aux publications normandes, reflétant les thématiques et tendances du moment.
    Ce nuage de mots-clés représente un échantillon des termes, les plus récents et les plus fréquents au global, associés aux publications normandes, reflétant les thématiques et tendances du moment.